A synergy recognized in the control of inflammation and repair of severe tissue damage.
BioSenic and its mission
BioSenic is an innovative company with the objective of addressing important unmet medical needs in the areas of innate immunity, inflammation and organ/function repair.
Our expertise is focused on cell therapy and the therapeutic use of arsenic trioxide (As2O3). BioSenic aims to become a leading company in the field of regenerative and immune medicine by developing innovative products for and autoimmune and inflammatory diseases.
BioSenic has a broad and diverse portfolio of solutions in clinical development in a variety of therapeutic areas targeting markets characterized by significant unmet medical needs and limited innovation.
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Our technology is based on two approaches:
Arsenic Trioxide : an innovative drug to treat autoimmune diseases at the source of the immune cascade. Medical arsenic is a small inorganic molecule with a strong therapeutic impact on pro-inflammatory responses. It modulates innate immunity and pro- and anti-inflammatory pathways with a dual mechanism of action:
- ROS-induced apoptosis of overactivated B and T cells.
- Reduction of the production of pro-inflammatory cytokines
ALLOB ® : a unique and proprietary approach to bone regeneration that transforms undifferentiated stem cells into "osteoblastic" or bone tissue reconstitution cells. The administration of these cells is performed in a minimally invasive manner, thus avoiding cumbersome surgical procedures.
Our lead clinical program:
cGVHD - Chronic Graft versus Host Disease.
For this indication, a Phase II study has already shown positive results: the first-line combination of arsenic trioxide and prednisone in cGVHD showed an overall response rate (ORR) at 6 months of 75%, which allows for a rapid reduction in corticosteroids
Medsenic is now finalizing the preparation of a Phase III trial. This study will be a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of oral arsenic trioxide (OATO) as a first-line treatment. The oral formulation, known as OATO - or ARSCICOR for autoimmune applications - has the characteristics of rapid gastrointestinal solubilization, optimal bioavailability comparable to the intravenous formulation (ARSCIMED, used in Phase II)
A positive Pre IND opinion from the FDA has been issued to initiate a Phase III clinical trial in this disease.
Executive team
Jean-Luc
Vandebroek
Director – Executive – permanent representative of Finsys Management SRL
Jean-Luc Vandebroek has extensive experience in large listed and private companies. Jean-Luc's career was built over 15 years at Delhaize (now Ahold Delhaize), the Belgian-American retail group. During this period, he held various positions of increasing responsibility within the finance department, such as CFO Europe and USA, and Vice President Finance Belgium and Luxembourg. He was then promoted to CFO of Fluxys, the listed European gas infrastructure operator. In this role, he was responsible for the financing of large infrastructure projects in the capital markets. Prior to joining Bone Therapeutics and then BioSenic, Jean-Luc was Director and CFO of Moteo Two Wheels and Bihr Europe, the two-wheeler specialist, a subsidiary of the Alcopa Group, a Belgian family-owned holding company with a turnover of around 1.7 billion euros.
Board of Directors
BioSenic is committed to implementing the highest processes and standards of corporate governance, while ensuring that its business model is relevant, efficient and cost effective to the Company and its investors.
The Board of Directors is made up of the Chairman, four non-executive Directors and two executive Directors.
Jean-François
Rax
Director – Non Executive – permanent representative of Capital Grand Est SAS
An engineer with a degree in Biochemistry and Biotechnology from INSA Lyon, Jean-François joined Capital Grand Est in 2014, an independent regional private equity company approved by the AMF with more than €180M in assets under management and which has been supporting more than 60 SMEs and start-ups in the Grand Est region since 2012. With 12 years of experience in venture & seed capital - 4 years in consulting and technology transfer - Inserm Transfert Initiative, Alcimed, Inra Transfert, Inserm Transfert, Jean-François is now a member of the Board of Directors / Director of Investments of Capital Grand Est.
Jean
Stéphenne
Director – Independent – permanent representative of Innoste SA
Jean Stéphenne has extensive experience in the life sciences industry, having held senior positions in numerous biotech and pharmaceutical companies, most recently as Chairman of the Board of TiGenix. Together with the TiGenix Board of Directors, he oversaw the clinical development and European marketing approval of the company's most advanced allogeneic cell therapy product for the treatment of perianal fistulas in Crohn's disease.
Previously, Jean Stéphenne was also a member of the Corporate Executive Team of GlaxoSmithKline (GSK) and Managing Director of GSK Biologicals (now GSK Vaccines). During his 40-year tenure, he built a company of 50 employees into a global leader in vaccine development, now with nearly 12,000 employees.
Jean Stéphenne currently serves on the Board of Directors of a number of life science companies including CureVac, Vaxxilon, OncoDNA and Bepharbel. He previously served as a director at Besix Group, BNP Paribas Fortis, GBL and IBA. In recognition of his contribution to the Belgian economy and global public health, he has received numerous awards and honors from the Belgian and British governments.
Jean-Luc
Vandebroek
Director – Executive – permanent representative of Finsys Management SRL
Jean-Luc Vandebroek has extensive experience in large listed and private companies. Jean-Luc's career was built over 15 years at Delhaize (now Ahold Delhaize), the Belgian-American retail group. During this period, he held various positions of increasing responsibility within the finance department, such as CFO Europe and USA, and Vice President Finance Belgium and Luxembourg. He was then promoted to CFO of Fluxys, the listed European gas infrastructure operator. In this role, he was responsible for the financing of large infrastructure projects in the capital markets. Prior to joining Bone Therapeutics and then BioSenic, Jean-Luc was Director and CFO of Moteo Two Wheels and Bihr Europe, the two-wheeler specialist, a subsidiary of the Alcopa Group, a Belgian family-owned holding company with a turnover of around 1.7 billion euros.
Revital
Rattenbach, PhD
Director - Independent
A seasoned biotech entrepreneur with over 15 years of experience, Revital Rattenbach is the CEO and founder of 4P Pharma, a clinical-stage biotech company specializing in active drug regeneration for the treatment of severe diseases. Under her leadership, 4P Pharma has established a unique, circular drug development platform that has brought two programs to the clinic while building a rich preclinical pipeline. Revital has initiated numerous academic and pharmaceutical collaborations worldwide and has completed a series of fundraising events since 4P Pharma was founded 8 years ago. Previously, Revital was the Managing Director and Founder of PharmaSeed Europe (2013-2014), a research organization focused on early stage development, where she oversaw all activities related to business development, finance and operations. Revital began her entrepreneurial career by co-founding Astem, a Sorbonne University spin-off specializing in endogenous adult stem cell activation. She holds a PhD in biology from the University of Paris VI and an MBA from the Sorbonne University.
BioSenic SA
Rue Granbonpré 11 – Bâtiment H (bte 24)
1435 Mont-St-Guibert – Belgium
T.: +32 493 09 73 66
info@biosenic.com
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